Description
Travelers’ diarrhea (TD) is a clinical syndrome resulting from ingestion of microbial contaminated food and water. It occurs during or shortly after travel, most commonly affecting persons traveling from an area of more highly developed hygiene and sanitation infrastructure to a less developed one. Thus, TD is defined more by circumstances of acquisition than by a specific microbial agent.
Etiology - cause
There is considerable diversity in etiologic (causative) agents. Bacteria are the most common cause of TD and are responsible for approximately 80%-85% of cases, parasites about 10%, and viruses 5%. These organisms enter your gastrointestinal tract and overwhelm your defense mechanisms and normal gut microbes, resulting in signs and symptoms of traveler's diarrhea. A similar but less common syndrome is toxic gastroenteritis, caused by ingestion of pre-formed toxins (ie botulism). In this syndrome, vomiting may predominate, and symptoms usually resolve within 12-18 hours. Often residents of less developed nations have become used to the bacteria and developed immunity to them.
Signs and Symptoms
Definitions of TD that rely on rigid criteria for frequency of loose stools in a 24-hour period are commonly used in clinical research studies but are not relevant to the clinical syndrome as it affects travelers.
The most common signs and symptoms of traveler's diarrhea are abrupt onset of:
Increased volume and weight of stool
Frequent loose stools — usually about four to five loose or watery bowel movements each day
Urgency
Abdominal cramps
Nausea
Vomiting – up to 15% of those affected
Fever
Bloating
Travelers’ diarrhea is generally self-limited (resolves without treatment) with significant improvement in 3-4 days and resolution in 1 week, but persistent symptoms may occur in a small percentage of travelers. A small number of cases involve moderate to severe dehydration, bloody stools, persistent vomiting or a high fever. If you or your child experiences any of these signs and symptoms or if the diarrhea lasts longer than a few days, it's time to see a doctor.
SIGNS OF DEHYDRATION – in need of IV rehydration
No urination for >8 hours
Sunken eyes
Lethargy
Confusion
Skin does not return after pinching
Dizziness or light-headedness
Crying without tears
High pulse rate and respiration rate
Prevention
For travelers to high-risk areas, the CDC recommends the following conservative approaches, which can minimize but never completely eliminate the risk of TD:
Wash hands with soap and water prior to eating or meal preparation.
Probiotics, such as Lactobacillus and Saccharomyces boulardii – daily ingestion of supplement or possibly yogurt helps to keep your intestinal bacteria healthy.
Care in selecting food and beverages for consumption may minimize the risk for acquiring TD. The following comprises a conservative approach, your disgression will need to weigh several factors about the country you are visiting .
AVOID
Drinking non-potable water and reconstitued beverages – even brushing teeth and ice cubes
Drinking water in the shower
Foods washed in non-potable water – ie salads
Street vendor food
Undercooked or raw meats, fish and shellfish
Buffets
Reheated prepared foods
Unpasteurized dairy products
CONSUME
Freshly cooked hot meals
Bottled, boiled, chemically treated (iodine) or microfiltered water
Sealed carbonated beverages
Dry foods – ie breads. pastries, cereals, nuts
Fruits and vegetables that you can peel – bananas, oranges, avocados
Treatment - allopathic (conventional)
Antibiotics are the principal element in the allopathic treatment of TD, although they are often not needed. Adjunctive agents used for symptomatic control may also be recommended.
ANTIBIOTICS
Bacterial causes of TD far outnumber other causes, so treatment with an antibiotic directed at bacterial pathogens of the intestines without testing remains the best allopathic therapy for TD. The effectiveness of a particular antimicrobial depends on the etiologic agent (bacteria, parasite or parasite) and its antibiotic sensitivity. First-line antibiotics include those of the fluoroquinolone class, such as ciprofloxacin or levofloxacin. Increasing microbial resistance to the fluoroquinolones may limit their usefulness in some destinations such as Thailand, Nepal and others. An alternative to the fluoroquinolones in this situation is azithromycin. Rifaximin has been approved for the treatment of TD caused by noninvasive strains of E. coli.
The standard treatment regimens consist of 3 days of antibiotic, although when treatment is initiated promptly, shorter courses, including single-dose therapy, may reduce the duration of the illness to a few hours. Antibiotic use should be follwed by use of probiotics to reduce the chance of sequelae (irritable bowel syndrome, dysbiosis)
ANTI-MOTILITY AGENTS
These agents include:
These provide a prompt decrease in stool frequency by reducing muscle spasms in your gastrointestinal tract, slowing the transit time through your digestive system and allowing more time for absorption. These agents should not be used by travelers in diarrheal illness associated with high fever or blood in the stool, rather they should seek medical attention. They are not recommended for children <12>
ORAL REHYDRATION THERAPY
Fluid and electrolytes (minerals) are lost in cases of TD, and replenishment is important, especially in young children or adults with chronic medical illness. In adult travelers who are otherwise healthy, severe dehydration resulting from TD is unusual unless persistent vomiting is present. Nonetheless, replacement of fluid losses remains an important adjunct to other therapy.
For more severe fluid loss, the CDC recommends replacement with oral rehydration solutions (ORS), such as World Health Organization ORS solutions (labelled WHO-ORS), which are widely available at stores and pharmacies in most developing countries. WHO-ORS is prepared by adding one packet to the appropriate volume of clean water (see packet for instructions). Once prepared, solutions should be consumed or discarded within 12 hours (24 hours if refrigerated). If vomitting is present, begin with sips of fluid and work up to larger volumes as tolerated.
TREATMENT FOR CHILDREN
In older children and teenagers, treatment recommendations for TD follow those for adults, with possible adjustments in dose of medication.
Macrolide antibiotics such as azithromycin are considered first-line antibiotic therapy in children, although some experts are using short-course fluoroquinolone therapy with caution for travelers younger than 18 yo. Rifaximin is approved for use starting at age 12 yo. Antimotility agents, loperamide and diphenoxylate, are not recommended for children <12>
Treatment – naturopathic
The mainstay of naturopathic treatment is preventive and then oral rehydration with electrolytes, natural antimicrobials, immune modulation and bulking of the stool to increase the time it takes for food to transit through the intestines (similar to antimotility agents).ORAL REHYDRATION – if WHO-ORS unavailable
1 Qt (or 1 Liter) water (clean)
1/2 tsp salt
1/2 tsp baking soda
2 Tbsp sugar or 1 Tbsp honey or 2 Tbsp rice powder
1/4 tsp potassium chloride (salt substitute – if available)
Sip every 15 min for a total of 1 C every 90 minutes as tolerated.
Alternatives if unable to gather the above ingredients
You or your child can drink the solution in small amounts throughout the day as a supplement to solid foods or formula, as long as dehydration persists. Small amounts reduce the likelihood of vomiting. Breast-fed infants also can drink the solution, but should continue nursing on demand. If dehydration symptoms don't improve, seek medical care. Oral rehydration solutions are intended only for urgent short-term use.
NATURAL ANTIMICROBIAL AGENTS
- Oregano oil – 3-5 drops in a small ammount of water
- Grapefruit seed extract (450mg per day) – aslo available in liquid which can be added to oregano oil
- Echinacea angustifolium or purpura, Hydrastis canadensis (goldenseal), Baptisia tinctora (baptisia) – equal parts; a classic tincture combination; ½ dropperful with a little water every 2 hours
- Glycyrrhiza galbra (licorice root) – great tasting
- Berberis aquifolium (oregon grape) – 50mg/kg/day (1lb = 2.2kg)
- Garlic
- Vitamin C – 1000mg 4-6 times daily (adult) or 250-500 mg 4-6 times daily (child 4-12yo)
- Activated charcoal – absorbs bacterial toxins in gut to reduce vomitting and diarrhea; take 1 dose after each bowel movement (8 tablets = 4 capsules = 1 Tbsp); may use burnt toast in a pinch; will darken stools
OTHER NATURAL TREATMENTS
- As your diarrhea improves eat mashed bananas, applesauce, bland cereals, crackers, clear soup, weak tea, dry toast or bread, rice
- Bulking agents – psyllium seed husk (1 Tbsp soaked overnight and followed by a glass of water); applesauce and carob powder (1/2 tsp carob in applesauce twice daily)
- Probiotics - Lactobocillis or Sacromyces boulardii; to help repopulate the intestines with friendly bacteria
See a Doctor When:
- Bloody diarrhea
- Fever in a child >102 degrees F
- Significant dehydration (see symptoms above)
- Persistent vomitting
- Vomitting after a head injury